The Immunogenicity of a Cell-derived H7N1 Split Influenza Virion Vaccine in Mice
نویسندگان
چکیده
منابع مشابه
A cell‐based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models
BACKGROUND In recent years, several avian influenza subtypes (H5, H7 and H9) have transmitted directly from birds to man, posing a pandemic threat. OBJECTIVES We have investigated the immunogenicity and protective efficacy of a cell based candidate pandemic influenza H7 vaccine in pre-clinical animal models. METHODS Mice and ferrets were immunised with two doses of the split virus vaccine (...
متن کاملLow immunogenicity of whole virion, verocell-derived, inactivated, pandemic influenza H1N1 vaccine in HIV-infected patients
HIV infected individuals face an increased risk of serious illness from influenza. Current guidelines recommend vaccination of all HIV infected adults. Several studies have analysed the immunogenicity of adjuvant H1N1 vaccines in these individuals. However, no such analysis exists for Celvapan (Baxter), an inactivated H1N1 vaccine without adjuvants, derived from verocells and based on whole vir...
متن کاملLong-term follow-up in patients with HIV vaccinated with pandemic influenza A(H1N1)/09 AS03-adjuvanted split virion vaccine and seasonal trivalent influenza split virion vaccine
INTRODUCTION In Sweden in 2009, two doses of the pandemic influenza A(H1N1)/09 AS03-adjuvanted split virion vaccine were recommended for those with HIV infection along with one dose of seasonal trivalent influenza vaccine (TIV). At that time, no data for HIV patients and their response to the adjuvanted vaccine were available. METHODS Forty-two HIV-infected individuals were vaccinated with th...
متن کاملImmunogenicity and safety of the 2015 Southern Hemisphere formulation of a split-virion inactivated quadrivalent vaccine
An inactivated split-virion quadrivalent influenza vaccine (IIV4; Fluzone® Quadrivalent; Sanofi Pasteur) has been available in the US since 2013 and in the Southern Hemisphere since 2015. Here, we describe the results of an open-label, post-licensure trial (WHO Universal Trial Number, U1111-1143-9256) to confirm the immunogenicity and safety of the Southern Hemisphere 2015 formulation of IIV4. ...
متن کاملImpact of Adjuvants on the Immunogenicity and Efficacy of Split-Virion H7N9 Vaccine in Ferrets.
BACKGROUND An effective vaccine is urgently needed against the H7N9 avian influenza virus. We evaluated the immunogenicity and protective efficacy of a split-virion H7N9 vaccine with or without the oil-in-water adjuvants in ferrets. METHODS Ferrets were vaccinated with 2 doses of unadjuvanted, MF59 or AS03-adjuvanted A/Shanghai/2/2013 (H7N9) vaccine, and the induction of antibodies to hemaggl...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Immunology
سال: 2009
ISSN: 0300-9475,1365-3083
DOI: 10.1111/j.1365-3083.2009.02254.x